Anastrozole: Generic, Uses, Side Effects, Dosages, Interactions, Warnings
You may need to have a negative pregnancy test before starting this treatment. Keep using birth control for at least 3 weeks after your last dose of anastrozole. Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).
- A dose-related increase was observed in the incidence of ovarian and uterine hyperplasia in females.
- They can discuss with you the risks and benefits of using this drug.
- Steady state concentration is reached after about 7 days of once-daily dosing.
- Anastrozole is also used to treat advanced breast cancer that has grown or spread after tamoxifen treatment.
- ARIMIDEX does not work in women with breast cancer who have not gone through menopause (premenopausal women).
It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone. Since only about 10% of https://www.odontotecnicicasati.it/groundbreaking-results-revealed-letrozol-2-5-mg/ is excreted unchanged in the urine, the renal impairment does not influence the total body clearance. Dosage adjustment in patients with renal impairment is not necessary [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY]. Patients should be informed that ARIMIDEX lowers the level of estrogen. This may lead to a loss of the mineral content of bones, which might decrease bone strength.
Similar outcomes with intermittent, continuous adjuvant letrozole in breast cancer
The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme. In animal studies, the drug did cause harm to fetuses when it was given to pregnant females. Keep in mind that animal studies don’t always predict what will happen in humans. However, based on how Arimidex works, it could be harmful to a human fetus if taken during pregnancy. The expiration date helps guarantee that the medication is effective during this time.
No dose adjustment is necessary for stable hepatic cirrhosis [see DOSAGE AND ADMINISTRATION and Use In Specific Populations]. One patient treated with ARIMIDEX discontinued the trial because of testicular enlargement. The mean baseline-subtracted change in testicular volume after 6 months of treatment was + 6.6 ± 7.9 cm³ in the ARIMIDEX-treated patients and + 5.2 ± 8.0 cm³ in the placebo group. Patients receiving ARIMIDEX had a lower incidence of hot flashes, vaginal bleeding, vaginal discharge, endometrial cancer, venous thromboembolic events and ischemic cerebrovascular events compared with patients receiving tamoxifen. Patients receiving ARIMIDEX had an increase in joint disorders (including arthritis, arthrosis and arthralgia) compared with patients receiving tamoxifen.
A Worldwide Yearly Survey of New Data in Adverse Drug Reactions
Results from the ATAC trial bone substudy at 12 and 24 months demonstrated that patients receiving Anastrozole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline. Anastrozole is a selective non-steroidal aromatase inhibitor and does not affect corticosteroids or aldosterone, the other hormones produced by the adrenal gland. Anastrozole is beneficial only in the treatment of estrogen-responsive breast cancers in postmenopausal women and has no benefits for premenopausal women. Of 1914 women in this subgroup who had earlier taken HRT, 777 (41%) developed joint symptoms, compared with 1001 of 3519 women (28%) who had not used HRT, a highly significant difference. Women with hormone-receptor-negative breast cancer developed significantly fewer joint symptoms than those with hormone-receptor-positive tumors.
- Some people using Arimidex may gain weight during treatment.
- Bisphosphonate treatment preserved bone density in most patients at risk of fracture.
- Moreover, 100 μmol l−1 atrazine also significantly inhibited antrum cavity formation and decreased the rate of mucification upon ovulatory stimulus.
- This is not a list of all drugs or health problems that interact with this drug.
You should take Arimidex according to your doctor’s or healthcare provider’s instructions. However, do not use more Arimidex than your doctor recommends. It’s not known if there is a dosage of Arimidex that could cause a life threatening overdose. However, if you have certain side effects of Arimidex, drinking alcohol could worsen them. These side effects include headaches, dizziness, nausea, and tiredness. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.
Table 11 below summarizes the results of trial 0030 and trial 0027 for the primary efficacy endpoints. BThe proportion of patients with 120 months’ follow-up was 29.8%. A The proportion of patients with 120 months’ follow-up was 29.4%. The growth of many cancers of the breast is stimulated or maintained by estrogens.
ARIMIDEX has not been studied in patients with severe hepatic impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY]. For patients with advanced breast cancer, the medication should be continued until tumor progression. Arimidex is a type of hormone therapy called an aromatase inhibitor. It works by stopping estrogen from being made in your body by the aromatase enzyme. On the other hand, tamoxifen is a type of hormone therapy called a selective estrogen receptor modulator (SERM).
Breast Cancer: Surprising Things That Can Help During and After Treatment
RxList does not provide medical advice, diagnosis or treatment. This is not a list of all drugs or health problems that interact with this drug. The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Inhibition of aromatase prevents the synthesis of oestrogens. Patients should be informed that an increased level of cholesterol might be seen while receiving Anastrozole.
7 Tamoxifen
However, the American Cancer Society notes that hormone therapy is sometimes used to treat a certain type of ovarian cancer called a stromal tumor. (Arimidex is considered a hormone therapy.) But keep in mind that this is an off-label use of the drug. If you take Arimidex to treat breast cancer before you’ve reached menopause, you’ll also need to take treatment that stops your ovaries from making estrogen. This is typically done with a type of drug called a luteinizing hormone-releasing hormone (LHRH) analog. Treatment may also be done using radiation on your ovaries or by having surgery to remove your ovaries.