We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
step 1. Van Driessche W, Lindemann B: Attention reliance regarding currents through unmarried sodium-choosy pores for the frog skin. Nature. 1979; 282 (5738): 519-520 PubMed Conceptual | Publisher Complete Text
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It means the latest good results put forward through this manuscript try maybe not justified and i usually do not accept new manuscript contained in this means
The new article authors features made clear many of the issues I raised within the my earlier remark. Sadly, all biggest issues haven’t been handled through this enhance. When i made in my personal earlier in the day opinion, We deem they impractical that the individuals points is going to be repaired only because of the a number of extra paragraphs. Instead there are still certain standard questions to your experimental build and you can, very vitally, to your studies.
It indicates the newest strong findings put forward from this manuscript try perhaps not warranted and that i try not to accept the manuscript inside mode
The new experts enjoys explained a number of the inquiries We raised in the my early in the day review. Unfortunately, all the biggest troubles haven’t been managed through this up-date. Once i made in my personal previous comment, I deem they unlikely that people items can be set only by a number of added paragraphs. As an alternative there are still some important questions to your fresh construction and you can, really vitally, for the studies.
- Best issue is that if I accompanied the newest malfunction out-of the methods in the previous variation it actually was it is possible to to help you decode, having almost perfect accuracy, people arbitrary stimulus names I picked. Find having examples of so it reanalysis. It doesn’t matter if we pretend your real stimulus seemed from the a later on go out otherwise is actually consistently alternating anywhere between laws and you will silence, the latest decryption is often close to finest. This is indicative that decryption doesn’t have anything to-do for the real stimuli heard by the Sender it is opportunistically exploiting different enjoys regarding analysis. The newest control study new people performed, treating new stimulus brands, you should never address this issue because it is suffering from exactly the same disease. Fundamentally, what the classifier try allegedly having fun with it’s time that has introduced as tape started.
- The cause of it is allegedly that people put low-independent investigation for degree and you will review. And when I know precisely (come across section 3), haphazard sampling 1 / 2 of information examples off a keen EEG shade commonly independent investigation. Repeating the analysis five times brand new handle investigation the brand new writers performed isnt an acceptable way to target which concern. Randomly interested in trials from a time show which includes sluggish change (like the slow revolution craft you to allegedly reigns over these types of tracks significantly less than these scenarios) will invariably consist of good temporary correlations. Come across TemporalCorrelations.jpg in for 2D thickness histograms and you may a correlation matrix indicating that it.
- Because the changed measures part brings increased detail now, it is still confused about what analysis were utilized. Traditional class data declaration just what data enjoys (typical articles throughout the analysis matrix) and you may exactly what observations (typical rows) were used. Anything would be a feature but generally it is the new other EEG avenues otherwise fMRI voxels an such like. Findings are time circumstances. Here I suppose the writers turned the fresh new brutal samples to your a great other room using dominating parts investigation. This is simply not said whether your dimensionality try shorter using the eigenvalues. Anyway, I suppose the info samples (amassed at 128 Hz) was in fact next made use of because observations together with EEG channels turned from the PCA were used given that has. The fresh new stimulus brands have been tasked while the For the otherwise Regarding for every single sample. A couple of 50% out of trials (and brands) was then chose randomly to own knowledge, as well as the other people was utilized to own comparison. Is this best?